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Where are stem
cells used?
EBMT guidelines
Medicine is now moving forward and the list of diseases in which stem cell transplantation is a therapeutic standard is becoming longer and longer. See what diseases may be treated using stem cells (according to the guidelines of the European organization dealing with stem cell transplantation - EBMT (European Society for Blood and Marrow Transplantation)).
List of medical conditions treated with stem cells
Acute leukaemias
- acute lymphoblastic leukaemia (ALL)
- acute myeloid leukaemia (AML)
- acute biphenotipic leukaemia
- poorly differentiated acute leukaemia
Chronic leukaemias
- chronic myeloid leukaemia (CML)
- chronic lymphocytic leukaemia (CLL)
- juvenile chronic myeloid leukaemia (JCML)
- juvenile myelomonocytic leukaemia (Naegeleg leukaemia) (JMML)
Myelodisplastic syndrome
- refractory anaemia (RA)
- refractory anaemia with ringed sideroblasts (RARS)
- refractory anaemia with excess blasts (RAEB)
- refractory anaemia with excess blasts in transformation (RAEB-T)
- chronic myelomonocytic leukaemia (CMML)
Diseases caused by stem cell defect
- aplastic anaemia(severe)
- Fanconi anaemia
- paroxysmal nocturnal haemoglobinuria
Myeloproliferative syndromes
- acute myelofibrosis
- myelofibrosis
- polycythaemia vera
- Essentials thromb ocythemia
Hyperplastic disorders of lymphatic system
- non-Hodgkin lymphoma
- acute lymphogranuloma
- prolimphocytic leukaemia
Phagocytic disorders
- Chediak-Higashi syndrome
- chronic granulomatous disease (CGD)
- neutrophil actin dysfunction
- reticular dysgenesis
Disorders caused by the absence or malfunctioning of enzymes
- mucopolysaccharidoses (MPS)
- Scheie syndrome (MPS-IS)
- Hunter syndrome(MPS-II)
- Sanfilippo syndrome (MPS-III)
- Morquio syndrome (MPS-IV)
- Maroteaux-Lamy syndrome (MPS-VI)
- Sly syndrome, beta- glucoronidase deficiency (MPS-VII)
- adrenoleukodystrophy
- mucolipidosis II
- Krabbe disease
- Gaucher disease
- Niemann-Pick disease
- Wolman disease
- metachromatic leukodystrophy
Histiocytic disorders
- familial erythrophagocytic lymphohistiocytosis
- histiocytosis -X
- hemophagocytosis
Inherited red blood cell abnormalities
- beta thalassemia
- pure red cell aplasia
- sickle cell anaemia
Inherited immune system disorders
- telangiectasia
- Kostmann syndrome
- leukocyte adhesion deficiency
- DiGeorge syndrome
- bare lymphocyte syndrome
- Omenn syndrome
- severe combined immunodeficiency (SCID)
- SCID adenosine deaminase deficiency
- SCID T and B lymphocytes negative
- SCID T lymphocytes negative and B lymphocytes positive
- common variable immunodeficiency
- Wiskotta Aldrich syndrome
- X-linked lymphoproliferative disorder
Other inherited conditions
- Lesch-Nyhan syndrome
- cartilage-hair hypoplasia
- Glanzmann’s thrombasthenia
- osteopetrosis (marble bone disease)
Hereditary thrombotic disorders
- mega-karyocytosis (inherited thrombocythemia)
Plasma cell disorders
- multiple myeloma
- plasmocythic leukaemia
- Waldenström’s macroglobulinemia
Other forms of cancer
- breast cancer
- Ewing’s sarcoma
- neuroblastoma (sympathicoblastoma)
- kidney cancer